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Here we describe a proof-of-principle, novel molecular imaging strategy for MM tumors using a VLA-4 targeted PET radiopharmaceutical, 64Cu-CB-TE1A1P-LLP2A. Cell uptake studies in a …
We observed tumor dose response to the activity administered to mice with B16-F10 melanoma. In summary, VLA-4 is broadly expressed across a variety of different cancer tissues and …
Feb 8, 2013 · A. Very late antigen-4 (VLA-4, also known as integrin α 4 β 1) is over expressed on MM cells. VLA-4 mediates myeloma cell adhesion to the bone marrow (BM) stroma through …
The integrin VLA-4 is expressed on the cell surfaces of stem cells, progenitor cells, T and B cells, monocytes, natural killer cells, eosinophils, but not neutrophils. It functions to promote an …
Apr 1, 2016 · Results: 64Cu-LLP2A and LLP2A-Cy5 demonstrated high specificity for VLA-4–positive mouse 5TGM1-GFP myeloma and nonmalignant inflammatory host cells such as T …
Jul 5, 2013 · Here, we describe the synthesis and characterization of the first small molecule agonist identified for the integrin α4β1 (also known as very late antigen-4 or VLA-4). The …
Jun 4, 2025 · We observed tumor dose response to the activity administered to mice with B16-F10 melanoma. In summary, VLA-4 is broadly expressed across a variety of different cancer …
Dec 2, 2016 · These data support the continued development of LLP2A as a molecular diagnostic imaging reagent for MM and as a potential therapeutic target of VLA-4 in MM. Ongoing studies …
Radiopharmaceutical therapy (RPT) is a promising approach to treating solid tumors, but therapeutic advances are impeded by the lack of broadly expressed targets and shared …
Jul 9, 2019 · The α 4 subunit can couple with either β 7 or β 1 subunits. α 4 β 1 integrin (also known as very late antigen-4, VLA-4) is expressed on leukocytes (lymphocytes, eosinophils, …
Integrins are cell adhesion receptors that mediate cell-to-cell, or cell-to-extracellular matrix adhesion. They represent an attractive target for treatment of multiple diseases. Two classes …
Jun 1, 2018 · The transmembrane α 4 β 1 integrin receptor, or very-late antigen 4 (VLA-4), is associated with tumor metastasis and angiogenesis, the development of chemotherapeutic …
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